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Mark Ridley: The Cooperative Gene : How Mendel's Demon Explains the Evolution of Complex Beings

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Why isn't all life pond-scum? Why are there multimillion-celled, long-lived monsters like us, built from tens of thousands of cooperating genes? Mark Ridley presents a new explanation of how complex large life forms like ourselves came to exist, showing that the answer to the greatest mystery of evolution for modern science is not the selfish gene; it is the cooperative gene. In this thought-provoking book, Ridley breaks down how two major biological hurdles had to be overcome in order to allow living complexity to evolve: the proliferation of genes and gene-selfishness. Because complex life has more genes than simple life, the increase in gene numbers poses a particular problem for complex beings. The more genes, the more chance for copying error; it is far easier to make a mistake copying the Bible than it is copying an advertising slogan. To add to the difficulty, Darwin's concept of natural selection encourages genes that look out for themselves, selfish genes that could easily evolve to sabotage the development of complex life forms. By retracing the history of life on our planet -- from the initial wobbly, replicating molecules, through microbes, worms, and flies, and on to humans -- Ridley reveals how life evolved as a series of steps to manage error and to coerce genes to cooperate within each body. Like a benign and unseen hand -- what Ridley calls "Mendel's Demon" -- the combination of these strategies enacts Austrian monk Gregor Mendel's fundamental laws of inheritance. This demon offers startling new perspectives on issues from curing AIDS, the origins of sex and gender, and cloning, to the genetics of angels. Indeed, if we are ever to understand the biology of other planets, we will need more than Darwin; we will need to understand how Mendel's Demon made the cooperative gene into the fundamental element of life. What does the cooperative gene tell us about our future? With genetic technology burgeoning around the world, we must ask whether life will evolve to be even more complex than we already are. Human beings, Ridley concludes, may be near the limit of the possible, at least for earthly genetic mechanisms. But in the future, new genetic and reproductive biosystems could allow our descendants to increase their gene numbers and therefore their complexity. This process, he speculates, could lead to the evolution of life forms far stranger and more interesting than anything humanly discovered or imagined so far. Written with uncommon energy, force, and clarity, The Cooperative Gene is essential reading for anyone wishing to see behind the headlines of our genetic age. It is an eye-opening invitation to the biotech adventure humanity has already embarked upon.

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Grosset: Max & Ruby's Busy Week

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It's a busy week for Max and Ruby: there's shopping to do, tea parties to throw, and cakes to bake for Grandma's birthday. From Monday to Sunday and every day in between, the fun never stops when you're hanging out with these two funny bunny siblings.

The year is 50BC, and all Gaul is occupied. Only one small village of indomitable Gauls still holds out against the invaders. But how much longer can Asterix, Obelix and their friends resist the mighty Roman legions of Julius Caesar? Anything is possible, with a little cunning plus the druid Getafix's magic potions! Their effects can be truly hair-raising... How to make God the real center of your life. With these seventeen steps, you'll be able to prevent your love for God from being diminished by day-to-day pressures. Fr. Leo J. Trese gives you solid ways to root out attachments that separate you from God. Success to the Brave is the fifteenth Richard Bolitho story and chronologically it follows the events covered by A Tradition of Victory. In Petit Collage Notecards ebook pdf the spring of 1802 Richard Bolitho is summoned to the Admiralty in London and given his orders for a difficult and, to him, distasteful task. Even an advanced promotion to vice-admiral to make him one of the youngest ever appointed does not compensate for his sudden and thankless mission. Bolitho and his wife are expecting their first child, and for once he is loath to quit the land for the demands of duty. The Peace of Amiens, signed a few weeks earlier, is already showing signs of strain as the old enemies wrangle over the return of colonial possessions won and lost during the war. In the little sixty-four-gun Achates Bolitho sails West for Boston, and thence to the Caribbean where he must hand over the island of San Felipe to the French. Bolitho discovers that to be a man of diplomacy is not enough, and as threat and counter-threat weave a web of intrigue around his lonely command he balances success against the danger to the men who must follow him even to the cannon's mouth.

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Ann Aschengrau,George R. Seage: Essentials of Epidemiology in Public Health

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Successfully tested in the authors' courses at Boston University and Harvard University, this text combines theory and practice in presenting traditional and new epidemiologic concepts. Broad in scope, the text opens with five chapters covering the basic epidemiologic concepts and data sources. A major emphasis is placed on study design, with separate chapters devoted to each of the three main analytic designs: experimental, cohort, and case-control studies. Full chapters on bias, confounding, and random error, including the role of statistics in epidemiology, ensure that students are well-equipped with the necessary information to interpret the results of epidemiologic studies. An entire chapter is also devoted to the concept of effect measure modification, an often-neglected topic in introductory textbooks. Up-to-date examples from the epidemiologic literature on diseases of public health importance are provided throughout the book. The Third Edition is a thorough update that offers: * New examples, the latest references, and public health statistics. * Nearly 50 new review questions. * Updated discussion of certain epidemiologic methods. * New figures depicting epidemiologic concepts.

Each of the weeks includes background information, a simple reflection, prayer helps, and Scripture readings, along with beautiful photography by Don Doll, SJ. This highly popular personal retreat was originally The Allergy-Free Cook Bakes Bread: Gluten-Free, Dairy-Free, Egg-Free download ebook pdf offered online through Creighton University's Online Ministries. A beautiful keepsake volume to accompany the beloved New York Times bestselling series Over the course of the bestselling Elm Creek Quilts series, readers have expressed a longing to visit Elm Creek Manor, meet the quilters themselves, and admire their beautiful creations. Jennifer Chiaverini s An Elm Creek Quilts Companion is the next best thing to a guided tour. Inside, readers will discover a treasure trove of delights, including the Bergstrom family tree, character biographies, quilt block illustrations, full-color photographs of quilts featured in the novels, and Behind the Scenes at Elm Creek Quilt Camp, an exclusive short story inspired by questions from real readers. No Elm Creek Quilts fan will want to be without this indispensable guide to the cherished series."

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Other End of the Leash

Lee Freeman-Shor: The Art of Execution: How the World's Best Investors Get it Wrong and Still Make Millions

Description

Over seven years, 45 of the world's top investors were given between $25m and $150m to invest by fund manager Lee Freeman-Shor. His instructions were simple. There was only one rule. They could only invest in their ten best ideas to make money. It seemed like a foolproof plan to make a lot of money. What could possibly go wrong? These were some of the greatest minds at work in the markets today - from top European hedge fund managers to Wall Street legends. But most of the investors' great ideas actually lost money. Shockingly, a toss of a coin would have been a better method of choosing whether or not to invest in a stock. Nevertheless, despite being wrong most of the time, many of these investors still ended up making a lot of money. How could they be wrong most of the time and still be profitable? The answer lay in their hidden habits of execution, which until now have only been guessed at from the outside world. This book lays bare those secret habits for the first time, explaining them with real-life data, case studies and stories taken from Freeman-Shor's unique position of managing these investors on a day-to-day basis.A riveting read for investors of every level, this book shows you exactly what to do and what not to do when your big idea is losing or winning - and demonstrates conclusively why the most important thing about investing is always the art of execution.

* Now what? Sensei is going on a blind date...with a girl!? Is this just to throw someone off? Or does he have a change of heart? Atsushi can only hope that this is some kind of joke. Normally, he would know how to deal with a male nemesis that would approach Sensei but this time - it's a girl..!? He has no clue how to combat this! Confused and depressed, Ma-chan tries to cheer Atsushi, but it's not really working. Can he overcome this frustrating feeling? In this extraordinary coming-of-age odyssey, Wally Lamb invites us to hitch a wild ride on a journey of love, The Art of Execution: How the World's Best Investors Get it Wrong and Still Make Millions free pdf pain, and renewal with the most heartbreakingly comical heroine to come along in years.Meet Dolores Price. She's 13, wise-mouthed but wounded, having bid her childhood goodbye. Stranded in front of her bedroom TV, she spends the next few years nourishing herself with the Mallomars, potato chips, and Pepsi her anxious mother supplies. When she finally orbits into young womanhood at 257 pounds, Dolores is no stronger and life is no kinder. But this time she's determined to rise to the occasion and give herself one more chance before she really goes under.

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Cary Elwes,Joe Layden,Rob Reiner: As You Wish: Inconceivable Tales from the Making of the Princess Bride

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From actor Cary Elwes, who played the iconic role of Westley in The Princess Bride, comes the New York Times bestselling account and behind-the-scenes look at the making of the cult classic film filled with never-before-told stories, exclusive photographs, and interviews with costars Robin Wright, Wallace Shawn, Billy Crystal, Christopher Guest, and Mandy Patinkin, as well as author and screenwriter William Goldman, producer Norman Lear, and director Rob Reiner. The Princess Bride has been a family favourite for close to three decades. Ranked by the American Film Institute as one of the top 100 Greatest Love Stories and by the Writers Guild of America as one of the top 100 screenplays of all time, The Princess Bride will continue to resonate with audiences for years to come. Cary Elwes was inspired to share his memories and give fans an unprecedented look into the creation of the film while participating in the twenty-fifth anniversary cast reunion. In As You Wish he has created an enchanting experience; in addition to never-before seen photos and interviews with his fellow cast mates, there are plenty of set secrets and backstage stories. With a foreword by Rob Reiner and original artwork by acclaimed artist Shepard Fairey, As You Wish is a must-have for all fans of this beloved film.

Soon after the fall of the Taliban, in 2001, Deborah Rodriguez went to Afghanistan as part of a group offering humanitarian aid to this war-torn nation. Surrounded by men and women whose skills as doctors, nurses, and therapists seemed eminently more practical than her Exorbitant Privilege: The Rise and Fall of the Dollar pdf own, Rodriguez, a hairdresser and mother of two from Michigan, despaired of being of any real use. Yet she soon found she had a gift for befriending Afghans, and once her profession became known she was eagerly sought out by Westerners desperate for a good haircut and by Afghan women, who have a long and proud tradition of running their own beauty salons. Thus an idea was born. Here is a book babies can really sink their gums into. Built for the way babies read, Indestructibles are printed on an amazing paperlike material that can t be ripped, torn, or punctured. Indestructibles are 100 percent safe and nontoxic, and if they get too funky, just throw them in the washing machine or dishwasher. They re made for baby to hold, grab, chew, pull, and bend, and are designed to create an even more special bond between reader and baby. Printed without words, the parent gets to make up the story, or just cuddle with baby while they explore together. Jungle Rumble! is about creatures in the wild. Kaaren Pixton s art is bright, swirling with color, and reminiscent of Eric Carle, and it attains an almost 3D richness on the special paperlike stock of the book.

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Little Houses: A Counting Book

Samuel Taylor Coleridge,Michael Sheen: Samuel Taylor Coleridge

Description

Hollywood actor Michael Sheen reads one of the most famous poems in the English language, "The Rime of the Ancient Mariner", in this collection, which is part of the Naxos AudioBooks "The Great Poets" series. Radical and daring, Coleridge worked with Wordsworth to transform poetry and bring it closer to the people. Original, atmospheric and pensive, the power of Coleridge's plain-spoken poetry inspired the tradition of Romantic poetry that sprung up in his wake. This popular anthology also contains Coleridge's other major narrative poem "Christabel", as well as "Kubla Khan", "Love", "Frost at Midnight" and "The Lime-Tree Bower My Prison".

The Lycian Way is Turkey's first and most popular long distance walking route. It has been extended by 2 days and now ends at the famous climbing walls at Geyikbayiri, 25km from Antalya. This new 2014 edition of the book includes all route updates and is designed to be used with the new Lycian Way i-phone application. How do you defeat a foe who can take control of your mind? That's the latest, and perhaps greatest, challenge that confronts Cole, Zane, Jay and Kai, the Masters of Spinjitzu! They better figure that out fast because one of them does indeed fall under the spell of the Hypnobrai! How will his fellow ninja react? The shocking answers, to these questions, await you in 'Rise of the Serpentine.' Beginning with the limited-edition volume "Sleeping with One Eye Open," published in 1964, Mark Strand was hailed as a poet of piercing originality and elegance, and in the ensuing decades he has not swerved from his vision The Veil free download pdf of how a poem should be shaped and what it should deliver. As he entered the middle period of his career, with volumes such as" The Continuous Life" (1990), Strand was already well-known for his ability to capture the subtle music of consciousness, and for creating painterly physical landscapes that could answer to the inner self: And here the dark infinitive to feel, / Which would endure and have the earth be still / And the star-strewn night pour down the mountains / Into the hissing fields and silent towns. In his later work, from "Blizzard of One "(1998) which won the Pulitzer Prize, through the sly, provocative riddles of his recent "Almost Invisible" (2012), Strand has delighted in reminding us that there is no poet quite like him for a dose of dark wit that turns out to be deep wisdom and self-deprecation. He has given voice to our collective imagination with a grandeur and comic honesty worthy of his great Knopf forebear Wallace Stevens. With this volume, we celebrate his canonical work."

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Chloe Neill: The Veil

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A brand new series from "New York Times" bestselling author Chloe Neill. "Seven years ago, the Veil that separates humanity from what lies beyond was torn apart, and New Orleans was engulfed in a supernatural war. Now, those with paranormal powers have been confined in a walled community that humans call the District.Those who live there call it Devil's Isle." Claire Connolly is a good girl with a dangerous secret: she s a Sensitive, a human endowed with magic that seeped through the Veil. Claire knows that revealing her skills would mean being confined to Devil s Isle. Unfortunately, hiding her power has left her untrained and unfocused. Liam Quinn knows from experience that magic makes monsters of the weak, and he has no time for a Sensitive with no control of her own strength. But when he sees Claire using her powers to save a human under attack in full view of the French Quarter Liam decides to bring her to Devil s Isle and the teacher she needs, even though getting her out of his way isn t the same as keeping her out of his head. As more and more Sensitives fall prey to their magic, and unleash their hunger on the city, Claire and Liam must work together to save New Orleans, or else the city will burn "

The Lycian Way is Turkey's first and most popular long distance walking route. It has been extended by 2 days and now ends at the famous climbing walls at Geyikbayiri, 25km from Antalya. This new 2014 edition of the book includes all route updates and is designed to be used with the new Lycian Way i-phone application. How do you defeat a foe who can take control of your mind? That's the latest, and perhaps greatest, challenge that confronts Cole, Zane, Jay and Kai, the Masters of Spinjitzu! They better figure that out fast because one of them does indeed fall under the spell of the Hypnobrai! How will his fellow ninja react? The shocking answers, to these questions, await you in 'Rise of the Serpentine.' Beginning with the limited-edition volume "Sleeping with One Eye Open," published in 1964, Mark Strand was hailed as a poet of piercing originality and elegance, and in the ensuing decades he has not swerved from his vision The Veil free download pdf of how a poem should be shaped and what it should deliver. As he entered the middle period of his career, with volumes such as" The Continuous Life" (1990), Strand was already well-known for his ability to capture the subtle music of consciousness, and for creating painterly physical landscapes that could answer to the inner self: And here the dark infinitive to feel, / Which would endure and have the earth be still / And the star-strewn night pour down the mountains / Into the hissing fields and silent towns. In his later work, from "Blizzard of One "(1998) which won the Pulitzer Prize, through the sly, provocative riddles of his recent "Almost Invisible" (2012), Strand has delighted in reminding us that there is no poet quite like him for a dose of dark wit that turns out to be deep wisdom and self-deprecation. He has given voice to our collective imagination with a grandeur and comic honesty worthy of his great Knopf forebear Wallace Stevens. With this volume, we celebrate his canonical work."

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Mick Wall: Prince: Purple Reign

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Prince was an icon. A man who defined an era of music and changed the shape of popular culture forever. There is no doubt that he was one of the most talented and influential artists of all time, and also one of the most mysterious. On 21st April 2016 the world lost its Prince; it was the day the music died. This book will open a door to Prince's world like never before - from his traumatic childhood and demonic pursuit of music as a means of escape, to his rise to superstardom, professional rivalries and marriages shrouded in tragedy, internationally bestselling music writer Mick Wall explores the historical, cultural and personal backdrop that gave rise to an artist the likes of which the world has never seen - and never will again. Mick, a lifelong Prince fan, was one of the first UK journalists to ever write about this enigmatic star, and it was his story that put Prince on the cover of Kerrang magazine in 1984 and inspired the biggest mailbag of letters the magazine has ever had. As Prince sang in '7', 'no one in the whole universe will ever compare', and this book is a shining tribute to the forever incomparable Prince.

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Vaughan Evans: The FT Essential Guide to Writing a Business Plan

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In one engaging, outcome-oriented book, The FT Essential Guide to Writing a Business Plan gives you: * The essential knowledge you need to write a winning business plan - quickly and without fuss * Guidance on how to focus throughout on the plan's purpose - to win backing * Samples of what a good plan looks like, so you can benchmark your own as you write it * Checklists, tips, examples and milestones to ensure you're on target * Prompts to reflect on, evaluate and learn from your experience With advice that's instantly applicable, whether your business is a start-up or a more established company looking to grow, this is the one guide you need to create a credible and persuasive plan.

Erich Fromm sees right to the heart of our contradictory needs for community and for freedom like no other writer before or since. In Fear of Freedom, Fromm warns that the The Gospel According to John and the Johannine Letters ebook pdf price of community is indeed high, and it is the individual who pays. Fascism and authoritarianism may seem like receding shadows for some, but are cruel realities for many. Erich Fromm leaves a valuable and original legacy to his readers - a vastly increased understanding of the human character in relation to society. At the beginning of the 21st century, it is more important than ever to be aware of his powerful message. Listen, and take heed. "Human Planet" is the first natural history documentary series to turn the camera on ourselves, the human species. Taking the same approach as Planet Earth, it will explain how human beings have learnt to live on every habitat, from our origins in the Jungle to our domination of Grasslands to the Desert, Ocean, Rivers, the creation of our own environment, Urban, and the challenges of the Arctic mountains. But this is also a story about how we have learnt to adapt to the most inhospitable landscapes and work in partnership with other animal species. From the Bajau sea gypsies to the Korowai tribe of West Papau who live in treehouses, the honey birds in Kenya that lead the Masai people to honey, the men who fish with dolphins in Brazil and the Papuan tribesmen who mimic the courtship dances of the birds of paradise, this is the remarkable story of our relationship with nature.

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